| Product Name |
Recombinant Human Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1) Protein |
| Product Overview |
This recombinant human Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1) protein includes amino acids 71-197aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q8WUK0 |
| Recommended Name |
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
| Gene Name |
PTPMT1 |
| Synonyms |
Protein tyrosine phosphatase, mitochondrial 1, DUSP23, FLJ46081, MOSP, PLIP, PNAS-129. |
| Species |
Human |
| Predicted Molecular Mass |
17 kDa |
| Expression System |
E.coli |
| Expression Range |
71-197aa |
| Tag |
N-6His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Signal Transduction |
| Target Function |
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity. |
| Subcellular Location |
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
| Protein Family |
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily |
