| Description |
Recombinant Human PS20 Protein is expressed from E.coli with His tag at the N-Terminus.It contains Lys32-Gln220. |
| Purity |
> 95% as determined by Tris-Bis PAGE |
| Accession |
Q9HC57 |
| Target Symbol |
PS20 |
| Synonyms |
Ps20; Wfdc1 |
| Species |
Human |
| Expression System |
E. coli |
| Tag |
N-His |
| Expression Range |
Lys32-Gln220 |
| Mol. Weight |
The protein has a predicted MW of 22 kDa. The protein migrates to 25-30 kDa based on Tris-Bis PAGE result. |
| Form |
Liquid |
| Formulation |
Supplied as 0.22um filtered solution in 20mM PB, 500mM NaCl, 200mM L-arginine (pH 7.4). |
| Endotoxin |
Less than 1EU per ug by the LAL method. |
| Storage |
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Shipping |
Shipped with dry ice. |
| Gene Background |
The whey acidic protein family member, WFDC1/ps20 is a permissivity factor in HIV infection. Herein we describe a contrasting role for ps20 in limiting MHV-1 infection. Intranasal MHV-1 infection produces a respiratory infection in mice. Using ps20 knockout mice we provide evidence that intranasal MHV-1 infection results in increased lung viral titers in ps20(-/-) compared to ps20(/) mice. Roles for ps20 in regulating expression of neutrophil-specific chemotactic factors, thereby potentially modulating neutrophil migration, and in modulating neutrophil susceptibility to MHV-1 infection. |
