| Product Name |
Recombinant Human Programmed Cell Death 1 Ligand 2 (PDL2/PDCD1LG2) Protein |
| Product Overview |
This recombinant human Programmed Cell Death 1 Ligand 2 (PDL2/PDCD1LG2) protein includes amino acids 33-236aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q9BQ51 |
| Recommended Name |
Programmed cell death 1 ligand 2 |
| Gene Name |
PDCD1LG2 |
| Synonyms |
Programmed cell death 1 ligand 2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2 |
| Species |
Human |
| Predicted Molecular Mass |
26.8 kDa |
| Expression System |
E.coli |
| Expression Range |
33-236aa |
| Tag |
N-6His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| Subcellular Location |
[Isoform 3]: Secreted.; [Isoform 2]: Endomembrane system; Single-pass type I membrane protein.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. |
| Protein Family |
Immunoglobulin superfamily, BTN/MOG family |
| Tissue Specificity |
Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
