| Product Name |
Recombinant Human Oligodendrocyte transcription factor 2 (OLIG2) Protein |
| Product Overview |
This recombinant human Oligodendrocyte transcription factor 2 (OLIG2) protein includes amino acids 1-323 of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitolprior to lyophilization. |
| Target Uniprot Id |
Q13516 |
| Recommended Name |
Oligodendrocyte transcription factor 2 |
| Gene Name |
OLIG2 |
| Synonyms |
BHLHB1; OLIGO2; PRKCBP2; RACK17; Basic Domain,Helix-Loop-Helix Protein,Class B 1; Class B basic helix-loop-helix protein 1; Class E basic helix-loop-helix protein 19 |
| Species |
Human |
| Predicted Molecular Mass |
49 kDa |
| Expression System |
E.coli |
| Expression Range |
1-323 |
| Tag |
N-6His+SUMO |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitol |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Epigenetics And Nuclear Signaling |
| Target Function |
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Subcellular Location |
Nucleus. Cytoplasm. |
| Associated Diseases |
A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. |
| Tissue Specificity |
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
