| Product Name |
Recombinant Human Nuclear Receptor Related 1 (NURR1/NR4A2) Protein |
| Product Overview |
This recombinant human Nuclear Receptor Related 1 (NURR1/NR4A2) protein includes amino acids 1-335 of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitolprior to lyophilization. |
| Target Uniprot Id |
P43354 |
| Recommended Name |
Nuclear receptor subfamily 4 group A member 2 |
| Gene Name |
NR4A2 |
| Synonyms |
NR4A2; RNR1; HZF-3; NOT; TINUR; Nuclear Receptor Subfamily 4,Group A,Member 2; Transcriptionally-inducible nuclear receptor; Immediate-early response protein NOT |
| Species |
Human |
| Predicted Molecular Mass |
41kDa |
| Expression System |
E.coli |
| Expression Range |
1-335 |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitol |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. |
| Subcellular Location |
Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization. |
| Protein Family |
Nuclear hormone receptor family, NR4 subfamily |
| Tissue Specificity |
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. |
