| Product Name |
Recombinant Human Thyroid Hormone Receptor Alpha (THRa/NR4A1) Protein |
| Product Overview |
This recombinant human Thyroid Hormone Receptor Alpha (THRa/NR4A1) protein includes amino acids 1-490aa of the target gene is expressed in E.coli.The protein is supplied in liquid form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P22736 |
| Recommended Name |
Nuclear receptor subfamily 4immunitygroup A member 1 |
| Gene Name |
NR4A1 |
| Synonyms |
THR-A; NR1A1; AR7; EAR7; ERB-T1; ERBA1; NR1-A1; THRA1; THRA2; c-ERBA1; Erythroblastic Leukemia Viral |
| Species |
Human |
| Predicted Molecular Mass |
59 kDa |
| Expression System |
E.coli |
| Expression Range |
1-490aa |
| Tag |
N-6His |
| Purity |
>95% |
| Formulation |
Liquid |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. |
| Subcellular Location |
Nucleus. Cytoplasm. Mitochondrion. |
| Protein Family |
Nuclear hormone receptor family, NR4 subfamily |
| Tissue Specificity |
Fetal muscle and adult liver, brain and thyroid. |
