| Product Name |
Recombinant Human Nectin-4/PVRL4 (NECTIN4) Protein |
| Product Overview |
This recombinant human Nectin-4/PVRL4 (NECTIN4) protein includes amino acids 31-351aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q96NY8 |
| Recommended Name |
Nectin-4 |
| Gene Name |
NECTIN4 |
| Synonyms |
PVRL4;Nectin-4;Ig superfamily receptor LNIR;Poliovirus receptor-related protein 4;PRR4;LNIR |
| Species |
Human |
| Predicted Molecular Mass |
35.3 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
31-351aa |
| Tag |
C-6His |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cell Biology, Cell Adhesion |
| Target Function |
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; (Microbial infection) Acts as a receptor for measles virus. |
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).; [Processed poliovirus receptor-related protein 4]: Secreted. Note=The secreted form is found in breast tumor patients (PubMed:15784625). |
| Protein Family |
Nectin family |
| Associated Diseases |
Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1) |
| Tissue Specificity |
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. |
