| Product Name |
Recombinant Human Thrombopoietin Receptor (TPOR/MPL) Protein |
| Product Overview |
This recombinant human Thrombopoietin Receptor (TPOR/MPL) protein includes amino acids 26-491aa of the target gene is expressed in 293F cell.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P40238 |
| Recommended Name |
Thrombopoietin receptor |
| Gene Name |
MPL |
| Synonyms |
CD110; C-MPL; MPLV; MPL; Thrombopoietin Receptor; Myeloproliferative leukemia protein; Proto-oncogen |
| Species |
Human |
| Predicted Molecular Mass |
68 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
26-491aa |
| Tag |
C-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. |
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cell surface. |
| Protein Family |
Type I cytokine receptor family, Type 1 subfamily |
| Associated Diseases |
Congenital amegakaryocytic thrombocytopenia (CAMT); Thrombocythemia 2 (THCYT2); Myelofibrosis with myeloid metaplasia (MMM) |
| Tissue Specificity |
Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. |
