| Product Name |
Recombinant Human Matrix Metalloproteinase 9 (MMP9) Protein |
| Product Overview |
This recombinant human Matrix Metalloproteinase 9 (MMP9) protein includes amino acids 20-707aa of the target gene is expressed in 293F cell.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P14780 |
| Recommended Name |
Matrix metalloproteinase-9 |
| Gene Name |
MMP9 |
| Synonyms |
GELB; Gelatinase B; CLG4B; CLG4-B; 92 KDa Gelatinase; 92kDa Type IV Collagenase |
| Species |
Human |
| Predicted Molecular Mass |
80 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
20-707aa |
| Tag |
N-6His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Developmental Biology |
| Target Function |
Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. |
| Subcellular Location |
Secreted, extracellular space, extracellular matrix. |
| Protein Family |
Peptidase M10A family |
| Associated Diseases |
Intervertebral disc disease (IDD); Metaphyseal anadysplasia 2 (MANDP2) |
| Tissue Specificity |
Detected in neutrophils (at protein level). Produced by normal alveolar macrophages and granulocytes. |
