| Product Name |
Recombinant Human Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 Protein |
| Product Overview |
This recombinant human Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 protein includes amino acids 31-487aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q9UNW1 |
| Recommended Name |
Multiple inositol polyphosphate phosphatase 1 |
| Gene Name |
MINPP1 |
| Synonyms |
Multiple Inositol Polyphosphate Phosphatase 1; 2,3-Bisphosphoglycerate 3-Phosphatase; 2,3-BPG Phosph |
| Species |
Human |
| Predicted Molecular Mass |
53.1 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
31-487aa |
| Tag |
C-6His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Signal Transduction |
| Target Function |
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy. |
| Subcellular Location |
Endoplasmic reticulum lumen. |
| Protein Family |
Histidine acid phosphatase family, MINPP1 subfamily |
| Associated Diseases |
Thyroid cancer, non-medullary, 2 (NMTC2) |
| Tissue Specificity |
Widely expressed with highest levels in kidney, liver and placenta. |
