| Product Name |
Recombinant Human Killer Cell Lectin Like Receptor Subfamily C, Member 2 (KLRC2) Protein |
| Product Overview |
This recombinant human Killer Cell Lectin Like Receptor Subfamily C, Member 2 (KLRC2) protein includes amino acids 19-190aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P26717 |
| Recommended Name |
NKG2-C type II integral membrane protein |
| Gene Name |
KLRC2 |
| Synonyms |
NKG2-C type II integral membrane protein, CD159c, NKG2-C, NKG2C. |
| Species |
Human |
| Predicted Molecular Mass |
23 kDa |
| Expression System |
E.coli |
| Expression Range |
19-190aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation. |
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein. |
| Tissue Specificity |
Expressed in NK cell subsets, in particular in adaptive CD57-positive NK cells (at protein level). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level). Expressed in alpha-beta T cells subsets (at protein level). KLRD1-K |
