| Product Name |
Recombinant Human Interleukin 1 Beta (IL1b) Protein |
| Product Overview |
This Recombinant Human Interleukin 1 Beta (IL1b) Protein with amino acids Val118-Ser269 is expressed in Mammalian Cell. The protein is supplied lyophilized and formulated in PBS.It has a purity >90% as determined by SDS-PAGE. |
| Target Uniprot Id |
P10749 |
| Synonyms |
IL1-B; IL1-Beta; IL1F2 |
| Species |
Human |
| Predicted Molecular Mass |
20 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
118-269aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology, Others |
| Target Function |
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. |
| Subcellular Location |
Cytoplasm, cytosol. Lysosome. Secreted, extracellular exosome. Cytoplasmic vesicle, autophagosome. Secreted. |
| Protein Family |
IL-1 family |
| Tissue Specificity |
Expressed in activated macrophages (at protein level). |
