| Product Name |
Recombinant Human Interleukin-4 Receptor Subunit Alpha/IL-4 Rα (IL4R) Protein |
| Product Overview |
This recombinant human Interleukin-4 Receptor Subunit Alpha/IL-4 Rα (IL4R) protein includes amino acids 26-231aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P24394 |
| Recommended Name |
Interleukin-4 receptor subunit alpha |
| Gene Name |
IL4R |
| Synonyms |
Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; |
| Species |
Human |
| Predicted Molecular Mass |
50.2 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
26-231aa |
| Tag |
C-Fc |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.; Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. |
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| Protein Family |
Type I cytokine receptor family, Type 4 subfamily |
| Tissue Specificity |
Isoform 1 and isoform 2 are highly expressed in activated T-cells. |
