| Product Name |
Recombinant Human Interleukin 12 Receptor Beta 2 (IL12Rb2) Protein |
| Product Overview |
This recombinant human Interleukin 12 Receptor Beta 2 (IL12Rb2) protein includes amino acids 24-622aa of the target gene is expressed in 293F cell.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
Q99665 |
| Recommended Name |
Interleukin-12 receptor subunit beta-2 |
| Gene Name |
IL12RB2 |
| Synonyms |
IL12R-B2; IL12-RB2; RP11-102M16.1 |
| Species |
Human |
| Predicted Molecular Mass |
110 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
24-622aa |
| Tag |
C-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. |
| Subcellular Location |
Membrane; Single-pass type I membrane protein. |
| Protein Family |
Type I cytokine receptor family, Type 2 subfamily |
| Tissue Specificity |
Isoform 2 is expressed at similar levels in both naive and activated T-cells. |
