| Product Name |
Recombinant Human Insulin Like Growth Factor 2 Receptor (IGF2R) Protein |
| Product Overview |
This recombinant human Insulin Like Growth Factor 2 Receptor (IGF2R) protein includes amino acids 43-1365aa of the target gene is expressed in 293F cell.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P11717 |
| Recommended Name |
Cation-independent mannose-6-phosphate receptor |
| Gene Name |
IGF2R |
| Synonyms |
CD222; IGF2-R; CIMPR; M6P-R; MPRI; Cation-Independent Mannose-6 Phosphate Receptor; M6P/IGF2 recepto |
| Species |
Human |
| Predicted Molecular Mass |
160 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
43-1365aa |
| Tag |
C-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Transport |
| Target Function |
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. |
| Subcellular Location |
Golgi apparatus membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. |
| Protein Family |
MRL1/IGF2R family |
