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Astor Scientific  |  SKU: ASTP2321

Human ICOS (Inducible T-Cell Costimulator) - Recombinant Protein

Molecule: ICOS
Species: Human
Expression System: Mammalian Cell
Tag: C-His&Fc
Expression Range: 1-141aa
$429.99 $549.99
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SDS-PAGE analysis of Human ICOS (Inducible T-Cell Costimulator) - Recombinant Protein, showing >90% purity under 15% SDS-PAGE (Reduced)
Astor Scientific

Human ICOS (Inducible T-Cell Costimulator) - Recombinant Protein

$429.99 $549.99

Product Overview

Product Name Recombinant Human ICOS / AILIM / CD278 Protein
Product Overview This recombinant human ICOS / AILIM / CD278 protein includes amino acids 1-141aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization.
Target Uniprot Id Q9Y6W8
Recommended Name Inducible T-cell costimulator
Gene Name ICOS
Synonyms AILIM;CD278;CVID1
Species Human
Predicted Molecular Mass 41.6 kDa
Expression System Mammalian Cell
Expression Range 1-141aa
Tag C-His&Fc
Purity >90%
Formulation Lyophilized
Buffer Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose
Storage Condition 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
Reconstitution Instruction Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%.
Applications Positive Control; Immunogen; SDS-PAGE; WB
Research Area Immunology
Target Function Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Subcellular Location [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Associated Diseases Immunodeficiency, common variable, 1 (CVID1)
Tissue Specificity Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral

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  • 100ug
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