| Product Name |
Recombinant Human 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Protein |
| Product Overview |
This recombinant human 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) protein includes amino acids 105-405aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P80365 |
| Recommended Name |
11-beta-hydroxysteroid dehydrogenase type 2 |
| Gene Name |
HSD11B2 |
| Synonyms |
AME; AME1; HSD11K; HSD2; SDR9C3; Short Chain Dehydrogenase/Reductase Family 9C,Member 3; NAD-depende |
| Species |
Human |
| Predicted Molecular Mass |
39 kDa |
| Expression System |
E.coli |
| Expression Range |
105-405aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. |
| Subcellular Location |
Microsome. Endoplasmic reticulum. |
| Protein Family |
Short-chain dehydrogenases/reductases (SDR) family |
| Associated Diseases |
Apparent mineralocorticoid excess (AME) |
| Tissue Specificity |
Expressed in kidney, pancreas, prostate, ovary, small intestine and colon. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis. |
