| Product Name |
Recombinant Human HER3 / ErbB3 Protein |
| Product Overview |
This recombinant human HER3 / ErbB3 protein includes amino acids 1-643aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P21860 |
| Recommended Name |
Receptor tyrosine-protein kinase erbB-3 |
| Gene Name |
ERBB3 |
| Synonyms |
c-erbB-3;c-erbB3;EEBB3;ErbB-3;erbB3-S;HER3;LCCS2;MDA-BF-1;p180-ErbB3;p45-sErbB3;p85-sErbB3 |
| Species |
Human |
| Predicted Molecular Mass |
70.2 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
1-643aa |
| Tag |
C-His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Target Function |
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Subcellular Location |
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted. |
| Protein Family |
Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily |
| Associated Diseases |
Lethal congenital contracture syndrome 2 (LCCS2) |
| Tissue Specificity |
Epithelial tissues and brain. |
