| Product Name |
Recombinant Human Histone H4 / HIST2H4A (H4C1) Protein |
| Product Overview |
This recombinant human Histone H4 / HIST2H4A (H4C1) protein includes amino acids 1-103aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P62805 |
| Recommended Name |
Histone H4 |
| Gene Name |
H4C1 |
| Synonyms |
FO108;H4;H4/A;H4/B;H4/C;H4/D;H4/E;H4/G;H4/H;H4/J;H4/K;H4/M;H4/N;H4F2;H4FA;H4FB;H4FC;H4FD;H4FE;H4FG;H |
| Species |
Human |
| Predicted Molecular Mass |
11.4 kDa |
| Expression System |
E.coli |
| Expression Range |
1-103aa |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Others |
| Target Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Subcellular Location |
Nucleus. Chromosome. |
| Protein Family |
Histone H4 family |
| Associated Diseases |
Chromosomal aberrations involving HISTONE H4 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;6)(q27;p21), with BCL6. |
