| Product Name |
Recombinant Human GPD1L Protein |
| Product Overview |
This recombinant human GPD1L protein includes amino acids 1-351aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q8N335 |
| Recommended Name |
Glycerol-3-phosphate dehydrogenase 1-like protein |
| Gene Name |
GPD1L |
| Synonyms |
Glycerol-3-phosphate dehydrogenase 1-like protein, GPD1-L. |
| Species |
Human |
| Predicted Molecular Mass |
40.6 kDa |
| Expression System |
E.coli |
| Expression Range |
1-351aa |
| Tag |
N-6His |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cell Biology |
| Target Function |
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. |
| Subcellular Location |
Cytoplasm. Note=Localized to the region of the plasma membrane. |
| Protein Family |
NAD-dependent glycerol-3-phosphate dehydrogenase family |
| Associated Diseases |
Brugada syndrome 2 (BRGDA2); Sudden infant death syndrome (SIDS) |
| Tissue Specificity |
Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs. |
