| Product Name |
Recombinant Human Growth Hormone Receptor (GHR) Protein |
| Product Overview |
This recombinant human Growth Hormone Receptor (GHR) protein includes amino acids 27-264aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P10912 |
| Recommended Name |
Growth hormone receptor |
| Gene Name |
GHR |
| Synonyms |
GHBP; Somatotropin receptor; Growth hormone-binding protein; Serum-binding protein |
| Species |
Human |
| Predicted Molecular Mass |
75 kDa |
| Expression System |
E.coli |
| Expression Range |
27-264aa |
| Tag |
C-6His-Fc |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Neuroscience, Cancer |
| Target Function |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.; Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. |
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. |
| Protein Family |
Type I cytokine receptor family, Type 1 subfamily |
| Associated Diseases |
Laron syndrome (LARS); Growth hormone insensitivity, partial (GHIP) |
| Tissue Specificity |
Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is hig |
