| Product Name |
Recombinant Human FOLR2 / FBP Protein |
| Product Overview |
This recombinant human FOLR2 / FBP protein includes amino acids 1-228aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P14207 |
| Recommended Name |
Folate receptor beta |
| Gene Name |
FOLR2 |
| Synonyms |
BETA-HFR;FBP;FBP/PL-1;FR-BETA;FR-P3 |
| Species |
Human |
| Predicted Molecular Mass |
26 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
1-228aa |
| Tag |
C-His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Metabolism |
| Target Function |
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. |
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. |
| Protein Family |
Folate receptor family |
| Tissue Specificity |
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. |
