| Product Name |
Recombinant Human Dual Specificity Phosphatase 6 (DUSP6) Protein |
| Product Overview |
This recombinant human Dual Specificity Phosphatase 6 (DUSP6) protein includes amino acids 1-300 of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitolprior to lyophilization. |
| Target Uniprot Id |
Q16828 |
| Recommended Name |
Dual specificity protein phosphatase 6 |
| Gene Name |
DUSP6 |
| Synonyms |
MKP3; PYST1; Mitogen-activated protein kinase phosphatase 3 |
| Species |
Human |
| Predicted Molecular Mass |
37 kDa |
| Expression System |
E.coli |
| Expression Range |
1-300 |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitol |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Neuroscience |
| Target Function |
Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
| Subcellular Location |
Cytoplasm. |
| Protein Family |
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily |
| Associated Diseases |
Hypogonadotropic hypogonadism 19 with or without anosmia (HH19) |
| Tissue Specificity |
Expressed in keratinocytes (at protein level). |
