| Product Name |
Recombinant Human VEGF Co Regulated Chemokine 1 (VCC1/CXCL17) Protein |
| Product Overview |
This recombinant human VEGF Co Regulated Chemokine 1 (VCC1/CXCL17) protein includes amino acids 24-119aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q6UXB2 |
| Recommended Name |
C-X-C motif chemokine 17 |
| Gene Name |
CXCL17 |
| Synonyms |
Chemokine (C-X-C motif) ligand 17 , Dcip1, DMC, MGC138300, UNQ473, VCC-1, VCC1 |
| Species |
Human |
| Predicted Molecular Mass |
41 kDa |
| Expression System |
E.coli |
| Expression Range |
24-119aa |
| Tag |
N-His-GST |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.; seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. |
| Subcellular Location |
Secreted. |
| Protein Family |
Intercrine alpha (chemokine CxC) family |
| Tissue Specificity |
Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation. |
