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Astor Scientific  |  SKU: ASTP8428

Human CD74 (Hla Class Ii Histocompatibility Antigen Gamma Chain) - Recombinant Protein

Molecule: CD74
Species: Human
Expression System: Mammalian Cell
Tag: N-6His
Expression Range: 73-296aa
$429.99 $549.99
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SDS-PAGE analysis of Human CD74 (Hla Class Ii Histocompatibility Antigen Gamma Chain) - Recombinant Protein, showing >95% purity under 15% SDS-PAGE (Reduced)
Astor Scientific

Human CD74 (Hla Class Ii Histocompatibility Antigen Gamma Chain) - Recombinant Protein

$429.99 $549.99

Product Overview

Product Name Recombinant Human Eukaryotic Cluster Of Differentiation 74 (CD74) Protein
Product Overview This recombinant human Eukaryotic Cluster Of Differentiation 74 (CD74) protein includes amino acids 73-296aa of the target gene is expressed in 293F cell.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization.
Target Uniprot Id P04233
Recommended Name HLA class II histocompatibility antigen gamma chain
Gene Name CD74
Synonyms HLA class II histocompatibility antigen gamma chain isoform b, DHLAG, HLADG, Ia-GAMMA II
Species Human
Predicted Molecular Mass 50 kDa
Expression System Mammalian Cell
Expression Range 73-296aa
Tag N-6His
Purity >95%
Formulation Lyophilized
Buffer Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose
Storage Condition 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
Reconstitution Instruction Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%.
Applications Positive Control; Immunogen; SDS-PAGE; WB
Research Area Immunology
Target Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.; Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.
Subcellular Location Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; [Isoform p41]: Late endosome. Lysosome.
Associated Diseases A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.
Tissue Specificity [Isoform p41]: In B cells, represents 10% of total CD74 expression.; [Isoform p33]: In B cells, represents 70% of total CD74 expression.

Size

  • 100ug
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