| Product Name |
Recombinant Human Cluster Of Differentiation 19 (CD19) Protein |
| Product Overview |
This recombinant human Cluster Of Differentiation 19 (CD19) protein includes amino acids 160-258aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P15391 |
| Recommended Name |
B-lymphocyte antigen CD19 |
| Gene Name |
CD19 |
| Synonyms |
B4; B-lymphocyte surface antigen B4; T-cell surface antigen Leu-12 |
| Species |
Human |
| Predicted Molecular Mass |
44 kDa |
| Expression System |
E.coli |
| Expression Range |
160-258aa |
| Tag |
N-His-GST |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge. |
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. |
| Associated Diseases |
Immunodeficiency, common variable, 3 (CVID3) |
| Tissue Specificity |
Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level). |
