| Product Name |
Recombinant Human Macrophage Inflammatory 5 (MIP5/CCL15) Protein |
| Product Overview |
This recombinant human Macrophage Inflammatory 5 (MIP5/CCL15) protein includes amino acids 22-113aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q16663 |
| Recommended Name |
C-C motif chemokine 15 |
| Gene Name |
CCL15 |
| Synonyms |
Chemokine (C-C motif) ligand 15, HCC-2, HMRP-2B, Lkn-1, LKN1, MIP-1d, MIP-5NCC-3, NCC3, SCYA15, SCYL |
| Species |
Human |
| Predicted Molecular Mass |
11 kDa |
| Expression System |
E.coli |
| Expression Range |
22-113aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Immunology |
| Target Function |
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. |
| Subcellular Location |
Secreted. |
| Protein Family |
Intercrine beta (chemokine CC) family |
| Tissue Specificity |
Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients. |
