| Product Name |
Recombinant Human Cathepsin D (CTSD) Protein |
| Product Overview |
This recombinant human Cathepsin D (CTSD) protein includes amino acids 21-412aa of the target gene is expressed in 293F cell.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P07339 |
| Recommended Name |
Cathepsin D |
| Gene Name |
CTSD |
| Synonyms |
CPSD; CLN10; Lysosomal Aspartyl Protease; Ceroid-Lipofuscinosis,Neuronal 10 |
| Species |
Human |
| Predicted Molecular Mass |
50 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
21-412aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Neuroscience |
| Target Function |
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. |
| Subcellular Location |
Lysosome. Melanosome. Secreted, extracellular space. |
| Protein Family |
Peptidase A1 family |
| Associated Diseases |
Ceroid lipofuscinosis, neuronal, 10 (CLN10) |
| Tissue Specificity |
Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level). |
