| Product Name |
Recombinant Human ASCC1 Protein |
| Product Overview |
This recombinant human ASCC1 protein includes amino acids 1-357aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q8N9N2 |
| Recommended Name |
Activating signal cointegrator 1 complex subunit 1 |
| Gene Name |
ASCC1 |
| Synonyms |
Activating signal cointegrator 1 complex subunit 1, ASC1p50, CGI-18, p50 |
| Species |
Human |
| Predicted Molecular Mass |
43.6 kDa |
| Expression System |
E.coli |
| Expression Range |
1-357aa |
| Tag |
N-6His |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Signal Transduction |
| Target Function |
Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. |
| Subcellular Location |
Nucleus. Nucleus speckle. |
| Associated Diseases |
Barrett esophagus (BE); Spinal muscular atrophy with congenital bone fractures 2 (SMABF2) |
| Tissue Specificity |
Ubiquitous. |
