| Product Name |
Recombinant Human Angiotensin II Receptor 1 (AGTR1) Protein |
| Product Overview |
This recombinant human Angiotensin II Receptor 1 (AGTR1) protein includes amino acids 263-359aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P30556 |
| Recommended Name |
Type-1 angiotensin II receptor |
| Gene Name |
AGTR1 |
| Synonyms |
AT1R; AG2S |
| Species |
Human |
| Predicted Molecular Mass |
41 kDa |
| Expression System |
E.coli |
| Expression Range |
263-359aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. |
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. |
| Protein Family |
G-protein coupled receptor 1 family |
| Associated Diseases |
Renal tubular dysgenesis (RTD) |
| Tissue Specificity |
Liver, lung, adrenal and adrenocortical adenomas. |
