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TribioScience | SKU: TBI4606-5MG

Rbin-1, Eukaryotic ribosome assembly inhibitor (TBI4606)

Name: Rbin-1, Eukaryotic ribosome assembly inhibitor (TBI4606)
Brand: TribioScience
SKU: TBI4606-5MG
Price: 90.0 USD
Availability: InStock

$90.00

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TribioScience

Rbin-1, Eukaryotic ribosome assembly inhibitor (TBI4606)

From $90.00

Description

Product Details

Formal Name: 3-[(2-Methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole

Molecular Formula: C₁₃H₁₂N₄S

Formula Weight: 256.33

CAS Number: 328023-11-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Eukaryotic ribosome assembly inhibitor

Functions

Rbin-1 is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly. The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein. Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus.