Quinacrine, Antiprotozoan; Anticancer (TBI4251)

Description

Product Details

Formal Name: 6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride

Molecular Formula: C₂₃H₃₀ClN₃O·₂HCl

Formula Weight: 472.88

CAS Number: 69-05-6

Purity: >98%

Formulation: powder

Solubility: Soluble in water (up to at least 25 mg/ml) or in DMSO ( up to at least 10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Antiprotozoan; Anticancer

Functions

Quinacrine is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent. It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS. Quinacrine displayed antitumor effects an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase. It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1. Quinacrine is also an inhibitor of phospholipase A2.

Application Procedures

First dissolved in water (up to at least 25 mg/ml) or in DMSO ( up to at least 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.