PIT-1, PH Domain antagonist (TBI1192)

Description

Product Details

Formal Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

Molecular Formula: C₁₄H₁₀ClN₃O₄S

Formula Weight: 351.76

CAS Number: 53501-41-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

PH Domain antagonist

Functions

PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87mgglioblastoma cells (IC50 = 37 μM). Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.