Piperlongumine, Glutathione sponge; Increases ROS (TBI2377)

Description

Product Details

Formal Name: (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one

Molecular Formula: C₁₇H₁₉NO₅

Formula Weight: 317.34

CAS Number: 20069-09-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

Glutathione sponge; Increases ROS

Functions

Elevates cellular levels of reactive oxygen species selectively in cancer cell lines. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular toxicity. Piperlongamine does not appear to have any effect on normal cells. Displays anti-tumor effects in a mouse xenograft tumor model as well as in spontaneously formed malignant breast tumors in mice. Elevation of ROS levels may be due to inhibition of ubiquitin-proteasome system at a pre-proteasomal step.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in water may be stored at -20°C for up to 3 months.