Picropodophyllotoxin, IGF1R inhibitor (TBI2189)

Description

Product Details

Formal Name: (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro¬-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3′,4′:6,7¬]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Molecular Formula: C₂₂H₂₂O₈

Formula Weight: 414.42

CAS Number: 477-47-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

IGF1R inhibitor

Functions

Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM. Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 – 15 μM. Exhibits antiangiogenic activitiy. Attenuates intimal hyperplasia after vascular injury. Active in vivo.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.