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TribioScience  |  SKU: TBI4034-5MG

PFI-3, Bromodomain inhibitor (TBI4034)

$106.00
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TribioScience

PFI-3, Bromodomain inhibitor (TBI4034)

From $106.00

Description

Product Details

Formal Name: (2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridine-2-yl)-2,5-diazabicyclo{2.2.1]heptan-2-yl]prop-2-en-1-one

Molecular Formula: C19H19N3O2

Formula Weight: 321.40

CAS Number: 1819363-80-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Bromodomain inhibitor

Functions

PFI-3 is a selective inhibitor of family VIII bromodomains PB1(5), SMARCA2, and SMARCA4. It showed complete selectivity over all non-family VIII bromodomains. PFI-3 blocked adipogenesis in C3H10T1/2 mesenchymal cells at 20µM.Treatment of embryonic stem cells with PFI-3 led to deprivation of stemness and deregulated lineage specificity. Differentiation of trophoblast stem cells in the presence of PFI-3 was enhanced. Cell permeable.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

Option

  • 5 MG
  • 25 MG
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