PFI-2 HCl (R-), Methyltransferase SETD7 inhibitor (TBI4033)

Description

Product Details

Formal Name: (1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride

Molecular Formula: C₂₃H₂₅F₄N₃O₃S HCl

Formula Weight: 535.98

CAS Number: 1627607-87-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Methyltransferase SETD7 inhibitor

Functions

(R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7. It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a SETD7-dependent manner.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.