PF-05089771, Nav1.7 inhibitor (selective) (TBI3990)

Description

Product Details

Formal Name: 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide

Alternate Names: PF771

Molecular Formula: C₁₈H₁₂Cl₂FN₅O₃S₂

Formula Weight: 500.34

CAS Number: 1235403-62-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Nav1.7 inhibitor (selective)

Functions

Potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7). It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 µM for resting channels. Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.