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TribioScience | SKU: TBI2159-5MG

PD-98059, MEK inhibitor (TBI2159)

Name: PD-98059, MEK inhibitor (TBI2159)
Brand: TribioScience
SKU: TBI2159-5MG
Price: 81.0 USD
Availability: InStock

$81.00

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Product Description

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TribioScience

PD-98059, MEK inhibitor (TBI2159)

From $81.00

Description

Product Details

Formal Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Alternate Names: 2’-Amino-3’-methoxyflavone

Molecular Formula: C₁₆H₁₃NO₃

Formula Weight: 267.29

CAS Number: 167869-21-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 6 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

MEK inhibitor

Functions

Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7μM). Accelerates differentiation of RAW264.7 cells into osteoclast-like cells. Mimics BMP4 in supporting self renewal of embryonic stem cells.