PD-98059, MEK inhibitor (TBI2159)

Description

Product Details

Formal Name: 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Alternate Names: 2’-Amino-3’-methoxyflavone

Molecular Formula: C₁₆H₁₃NO₃

Formula Weight: 267.29

CAS Number: 167869-21-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 6 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

MEK inhibitor

Functions

Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7μM). Accelerates differentiation of RAW264.7 cells into osteoclast-like cells. Mimics BMP4 in supporting self renewal of embryonic stem cells.

Application Procedures

First dissolved in DMSO (up to 6 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.