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TribioScience | SKU: TBI2161-5MG

PD-325901, MEK inhibitor (TBI2161)

Name: PD-325901, MEK inhibitor (TBI2161)
Brand: TribioScience
SKU: TBI2161-5MG
Price: 99.0 USD
Availability: InStock

$99.00

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TribioScience

PD-325901, MEK inhibitor (TBI2161)

From $99.00

Description

Product Details

Formal Name: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

Molecular Formula: C₁₆H₁₄F₃IN₂O₄

Formula Weight: 482.20

CAS Number: 391210-10-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 12 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

MEK inhibitor

Functions

A selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM). Inhibits growth and/or proliferation of a variety of cancer cells. Enhances self-renewal of embryonic stem cells. In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells. In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.