PD-150606, Calpain inhibitor (TBI1515)

Description

Product Details

Formal Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid

Molecular Formula: C₉H₇IO₂S

Formula Weight: 306.12

CAS Number: 179528-45-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Calpain inhibitor

Functions

A selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices. Displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death. Some protective effects may be due to inhibition of MMP activity.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.