PBD-150, Glutaminyl cyclase inhibitor (TBI4885)

Description

Product Details

Formal Name: 1-(3,4-Dimethoxyphenyl)-3-93-imidazol-1-ylpropyl)thiourea

Molecular Formula: C₁₅H₂₀N₄O₂S

Formula Weight: 320.4

CAS Number: 790663-33-1

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Glutaminyl cyclase inhibitor

Functions

Inhibitor of human glutaminyl cyclase (IC50 = 60 nM). PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.