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TribioScience | SKU: TBI2616-5MG

Oridonin, HSP70 inhibitor; Inflammasome inhibitor (TBI2616)

Name: Oridonin, HSP70 inhibitor; Inflammasome inhibitor (TBI2616)
Brand: TribioScience
SKU: TBI2616-5MG
Price: 90.0 USD
Availability: InStock

$90.00

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Product Description

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TribioScience

Oridonin, HSP70 inhibitor; Inflammasome inhibitor (TBI2616)

From $90.00

Description

Product Details

Formal Name: 7a,20-Epoxy-1a,6b,7,14-tetrahydroxykaur-16-en-15-one

Alternate Names: Isodonol

Molecular Formula: C₂₀H₂₈O₆

Formula Weight: 364.43

CAS Number: 28957-04-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming).

Storage: -20°C

Stability: ≥ 2 years.

Applications

HSP70 inhibitor; Inflammasome inhibitor

Functions

A potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models. Inhibits vascular inflammation in vivo. Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling. Inhibits migration, invasion and adhesion of melanoma cells. Induces apoptosis in osteosarcoma cells by multiple pathways.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

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