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TribioScience | SKU: TBI2660-5MG

Obatoclax (GX15-070), Bcl-2 antagonist. Induces apoptosis (TBI2660)

Name: Obatoclax (GX15-070), Bcl-2 antagonist. Induces apoptosis (TBI2660)
Brand: TribioScience
SKU: TBI2660-5MG
Price: 126.0 USD
Availability: InStock

$126.00

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TribioScience

Obatoclax (GX15-070), Bcl-2 antagonist. Induces apoptosis (TBI2660)

From $126.00

Description

Product Details

Formal Name: 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate

Alternate Names: GX15-070

Molecular Formula: C₂₀H₁₉N₃O · CH₃SO₃H

Formula Weight: 413.50

CAS Number: 803712-79-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 5 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Bcl-2 antagonist. Induces apoptosis

Functions

A novel Bcl-2 homology domain-3 (BH3) mimetic. Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM). Synergizes with other agents such as chloroquine and cytarabine in cytotoxicity against a variety of cancer cells.