NSC-95397, CtBP inhibitor; cdc25 phosphatase inhibitor (TBI1565)

Description

Product Details

Formal Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone

Molecular Formula: C₁₄H₁₄O₄S₂

Formula Weight: 310.39

CAS Number: 93718-83-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 1 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

CtBP inhibitor; cdc25 phosphatase inhibitor

Functions

A potent and selective inhibitor of Cdc25 phosphatase (Ki = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition. Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2. Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes. Induces eryptosis in human erythrocytes.

Application Procedures

First dissolved in DMSO (up to 15 mg/ml) or in Ethanol (up to 1 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.