Nigericin Na, Induces rapid intracellular acidification (TBI2089)

Description

Product Details

Alternate Names: Antibiotic K178; Antibiotic X-464; Azalomycin M; PolyetherinA

Molecular Formula: C₄₀H₅₇O₁₁Na

Formula Weight: 746.96

CAS Number: 28643-80-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Induces rapid intracellular acidification

Functions

Polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity is K+> Rb+> Cs+>>Na+. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.