NGI-1 Oligosaccharyltransferase (OST) inhibitor (TBI4291)

Description

Product Details

Formal Name: 5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide

Alternate Names: ML414

Molecular Formula: C₁₇H₂₂N₄O₃S₂

Formula Weight: 394.51

CAS Number: 790702-57-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 5 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Oligosaccharyltransferase (OST) inhibitor

Functions

NGI-1 is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 µM. It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika). It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation.

Application Procedures

First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.