| Description |
Recombinant Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail&Gly22-Ser679(ITGB8) basic tail. |
| Purity |
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Accession |
P43406(ITGAV)&Q0VBD0(ITGB8) |
| Target Symbol |
Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer |
| Synonyms |
Integrin alpha V beta 8；ITGAV&ITGB8 |
| Species |
Mouse |
| Expression System |
HEK293 |
| Tag |
C-His |
| Expression Range |
Phe31-Val988(ITGAV)acidic tail & Gly22-Ser679(ITGB8)basic tail |
| Mol. Weight |
The protein has a predicted MW of 111.6(ITGAV)&76.6(ITGB8) kDa. Due to glycosylation, the protein migrates to 80-140 kDa based on Tris-Bis PAGE result. |
| Form |
Lyophilized |
| Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Endotoxin |
Less than 1EU per ug by the LAL method. |
| Activity |
Immobilized Mouse ITGAV&ITGB8, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.97ug/ml determined by ELISA. Contact us for detailed testing images. |
| Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipping |
Shipped at ambient temperature. |
| Gene Background |
Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation. |
