| Description |
Recombinant Mouse Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr24-His1087 (ITGAL) acidic tail & Gln24-Asn702 (ITGB2) basic tail. |
| Purity |
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Accession |
P24063-1(ITGAL)&P11835(ITGB2) |
| Target Symbol |
Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer |
| Species |
Mouse |
| Expression System |
HEK293 |
| Tag |
C-His |
| Expression Range |
Tyr24-His1087 (ITGAL) acidic tail & Gln24-Asn702 (ITGB2) basic tail |
| Mol. Weight |
The protein has a predicted MW of 123.30 kDa (ITGAL) and 79.60 kDa (ITGB2). Due to glycosylation, the protein migrates to 160-180 kDa (ITGAL) and 90-105 kDa (ITGB2) based on Tris-Bis PAGE result. |
| Form |
Lyophilized |
| Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Endotoxin |
Less than 1EU per ug by the LAL method. |
| Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipping |
Shipped at ambient temperature. |
| Gene Background |
Integrin αLβ2 is one member of the integrin family and also called leukocyte function-associated antigen-1 (LFA-1). It is widely expressed on T lymphocytes and controls the function and, in particular, the migration of immune cells[1]. Active αLβ2 can bind ICAM1/CD54, ICAM2, ICAM3 and JAM1[2]. |
