| Description |
Recombinant Mouse Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail. |
| Purity |
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Accession |
Q9QUM0(ITGA2B)&O54890(ITGB3) |
| Target Symbol |
Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer |
| Synonyms |
ITGA2B&ITGB3 ITGA2B; ITGB3 |
| Species |
Mouse |
| Expression System |
HEK293 |
| Tag |
C-His |
| Expression Range |
Leu32-Arg988(ITGA2B) acidic tail & Glu26-Asp717(ITGB3) basic tail |
| Mol. Weight |
The protein has a predicted MW of 109.80 kDa (ITGA2B)&80.80 kDa (ITGB3). Due to glycosylation, the protein migrates to 90-113 kDa based on Tris-Bis PAGE result. |
| Form |
Lyophilized |
| Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Endotoxin |
Less than 1EU per ug by the LAL method. |
| Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipping |
Shipped at ambient temperature. |
| Gene Background |
Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction. |
